How does Rimonabant work?

Rimonabant acts by selectively blocking CB1 receptors found in the brain and in peripheral organs important in glucose and lipid (or fat) metabolism, including adipose tissue, the liver, gastrointestinal tract and muscle1.Rimonabant switches off the same brain circuits that make people hungry when they smoke cannabis CB1 receptor blockade with Rimonabant acts to decrease the overactivity of the endocannabinoid system (EC system)2,3. The EC system is a recently characterised physiological system that includes receptors such as the CB1 receptor and it has been shown to play an important role in regulating body weight and in controlling energy balance, as well as glucose and lipid (or fat) metabolism.

What is Rimonabant used for?

Rimonabant acts by selectively blocking CB1 receptors found in the brain and in peripheral organs important in glucose and lipid (or fat) metabolism, including adipose tissue, the liver, gastrointestinal tract and muscle1.Rimonabant switches off the same brain circuits that make people hungry when they smoke cannabis CB1 receptor blockade with Rimonabant acts to decrease the overactivity of the endocannabinoid system (EC system)2,3. The EC system is a recently characterised physiological system that includes receptors such as the CB1 receptor and it has been shown to play an important role in regulating body weight and in controlling energy balance, as well as glucose and lipid (or fat) metabolism.

Does Rimonabant also aid smoking cessation?

Clinical trials have shown that heavy smokers, after being on a regular supplement of Rimonabant, have stopped smoking altogether. Smokers usually do not stop smoking for fear of weight-gain, which can be highly discouraging. However since Rimonabant works on the overeating and smoking factors simultaneously such problems wouldn’t arise.

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